Butte N F, Wong W W, Fiorotto M, Smith E O, Garza C
USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Tex., USA.
Biol Neonate. 1995;67(6):414-24. doi: 10.1159/000244194.
To determine the effect of infant feeding mode on body composition, a cross-sectional study was designed in which 10 breast-fed and 10 formula-fed infants were studied at 1 month of age, and another 10 breast-fed and 10 formula-fed infants at 4 months of age. Anthropometric measurements included body weights, lengths, selected diameters, circumferences and skinfold thicknesses. Total body water (TBWO) was measured by 18O dilution. A dose equivalent to 300 mg 18O/kg body weight was administered orally to the infants. Fat-free mass (FFMO) was calculated from TBWO using reference hydration constants of 0.805 and 0.798 at 1 and 4 months, respectively. Body fatO was taken as the difference between weight and FFMO. Total-body electrical conductivity (TOBEC) measurements were used to estimate FFMT and FATT. ANOVA was used to analyze the anthropometric and body composition data using feeding mode and age as grouping factors. Anthropometric measurements did not differ by feeding mode. TBW (kg) and FFM (kg) and body fat (kg) derived from 18O dilution or TOBEC did not differ by feeding mode. TBWO,T (%wt), FFMO,T (%wt), and body fatO,T (%wt) derived from 18O dilution and TOBEC differed significantly between the breast-fed and formula-fed infants at 4 months of age (p < 0.05). Expressed as a percentage of body weight, TBWO and FFMO,T were higher and body fatO,T was lower among the 4-month formula-fed infants.
为了确定婴儿喂养方式对身体成分的影响，设计了一项横断面研究，其中选取了10名母乳喂养和10名配方奶喂养的1月龄婴儿进行研究，另外还选取了10名母乳喂养和10名配方奶喂养的4月龄婴儿。人体测量指标包括体重、身长、选定的直径、周长和皮褶厚度。采用18O稀释法测量全身水含量（TBWO）。向婴儿口服给予相当于300 mg 18O/kg体重的剂量。分别使用1月龄和4月龄时的参考水合常数0.805和0.798，根据TBWO计算去脂体重（FFMO）。体脂O取体重与FFMO之差。使用全身电阻抗（TOBEC）测量法估算去脂瘦体重（FFMT）和体脂肪（FATT）。以喂养方式和年龄作为分组因素，采用方差分析来分析人体测量和身体成分数据。人体测量指标在不同喂养方式之间没有差异。通过18O稀释法或TOBEC得出的TBW（kg）、FFM（kg）和体脂肪（kg）在不同喂养方式之间没有差异。在4月龄时，通过18O稀释法和TOBEC得出的母乳喂养和配方奶喂养婴儿之间的TBWO、T（%体重）、FFMO、T（%体重）和体脂肪O、T（%体重）存在显著差异（p<0.05）。以体重百分比表示，4月龄配方奶喂养婴儿的TBWO和FFMO、T较高，而体脂肪O、T较低。
