Jakab F, Sugár I, Dömötör L, Ondrejka P, Gergely L
Acta Chir Acad Sci Hung. 1978;19(4):357-62.
Cholesterol gallstones were induced in mice by means of a lithogenous diet. Some of the animals were given in addition morphine regularly. The ten-week experiment was concluded with operation. Lithogenesis was recorded, the volume of the gallbladder was measured, the bile collected for analysis and a specimen was taken from the liver for histologic examination. In the animals fed the lithogenous diet were only gallstones found. The occurrence of cholestasis was unequivocally be proved by the volume of the gallbladder and the microscopic examination of the bile sediment in the group treated with morphine. Metabolic factors seem to play the primary role in the formation of cholesterol gallstones; cholestasis is of secondary importance.
通过给予致石性饮食在小鼠中诱发胆固醇胆结石。部分动物还定期给予吗啡。为期十周的实验以手术结束。记录结石形成情况，测量胆囊体积，收集胆汁进行分析，并取肝脏标本进行组织学检查。在喂食致石性饮食的动物中仅发现了胆结石。通过吗啡治疗组胆囊的体积以及胆汁沉淀物的显微镜检查明确证实了胆汁淤积的发生。代谢因素似乎在胆固醇胆结石的形成中起主要作用；胆汁淤积起次要作用。
