Duhault J, Boulanger M, Espinal J, Marquié G, Petkov P, du Boistesselin R
Division of Metabolic Diseases, Institut de Recherches Servier, Suresnes, France.
Acta Diabetol. 1995 Jun;32(2):92-4. doi: 10.1007/BF00569564.
Recent data suggest that in a proportion of NIDDM patients there is a slowly evolving insulitis which results in a latent autoimmune diabetes leading to full insulin-dependence. Many animal models exist of NIDDM but none have reported the spontaneous existence of a similar phenomenon. We have re-examined the histology of pancreata from a few Psammomys obesus who had become insulin-dependent in the late stages of NIDDM. We report here the unexpected finding of the presence of insulitis in these animals and suggest that they could be a model for the clinical observation of latent IDDM in NIDDM patients.
近期数据表明，在一部分非胰岛素依赖型糖尿病（NIDDM）患者中，存在一种缓慢进展的胰岛炎，这会导致潜在的自身免疫性糖尿病，最终发展为完全胰岛素依赖。有许多NIDDM的动物模型，但均未报道过类似现象的自发存在。我们重新检查了几只肥胖沙鼠胰腺的组织学情况，这些沙鼠在NIDDM晚期已变为胰岛素依赖型。我们在此报告这些动物中存在胰岛炎这一意外发现，并表明它们可能是用于临床观察NIDDM患者潜在胰岛素依赖型糖尿病（IDDM）的模型。
