Turgay K, Marahiel M A
Philipps Universität Marburg, Germany.
DNA Seq. 1995;5(5):283-90. doi: 10.3109/10425179509030982.
We identified, cloned and sequenced an operon comprising of two genes gtcR and gtcS located adjacent to the grs operon of Bacillus brevis, which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S. The transcription initiation site of the gtcRS operon was determined in Bacillus brevis and Bacillus subtilis. The encoded proteins GtcR and GtcS were identified as members of the two-component system family of signal transducing proteins.
我们鉴定、克隆并测序了一个操纵子，该操纵子由两个基因gtcR和gtcS组成，它们位于短短芽孢杆菌的grs操纵子附近，grs操纵子编码参与肽抗生素短杆菌肽S生物合成的多酶。在短短芽孢杆菌和枯草芽孢杆菌中确定了gtcRS操纵子的转录起始位点。编码的蛋白质GtcR和GtcS被鉴定为信号转导蛋白的双组分系统家族成员。
