Gupta S
Division of Basic and Clinical Immunology, University of California, Irvine, USA.
Drugs Aging. 1995 Jul;7(1):19-29. doi: 10.2165/00002512-199507010-00003.
P-Glycoprotein is a member of a superfamily of adenosine triphosphate-binding cassette transporter proteins and plays an important role in multidrug resistance in cancer cells. P-Glycoprotein is known to transport a wide variety of substances ranging from ions to peptides. P-Glycoprotein is expressed on a variety of normal cells, however its physiological function is unclear. The apical and polar distribution on secretory cells suggests a secretory role for P-glycoprotein. More recently, cells of the immune system have been shown to express P-glycoprotein. There is evidence to suggest that P-glycoprotein may play a role in the secretion of certain cytokines (especially those lacking signal sequence) and cytotoxic molecules. In this article, the basic structure, gene regulation and expression of P-glycoprotein are reviewed. Furthermore, age-related changes in the expression of P-glycoprotein and potential effects on drug therapy in the elderly are discussed.
P-糖蛋白是三磷酸腺苷结合盒转运蛋白超家族的成员之一，在癌细胞的多药耐药中起重要作用。已知P-糖蛋白可转运从离子到肽等多种物质。P-糖蛋白在多种正常细胞上表达，但其生理功能尚不清楚。分泌细胞上的顶端和极性分布表明P-糖蛋白具有分泌作用。最近，已证明免疫系统的细胞表达P-糖蛋白。有证据表明P-糖蛋白可能在某些细胞因子（尤其是那些缺乏信号序列的细胞因子）和细胞毒性分子的分泌中起作用。本文综述了P-糖蛋白的基本结构、基因调控和表达。此外，还讨论了P-糖蛋白表达的年龄相关变化及其对老年人药物治疗的潜在影响。
