生物化学中的锌金属化学

Zinc metallochemistry in biochemistry.

作者信息

Vallee B L, Auld D S

机构信息

Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, MA 02115, USA.

出版信息

EXS. 1995;73:259-77. doi: 10.1007/978-3-0348-9061-8_12.

DOI:10.1007/978-3-0348-9061-8_12

PMID:7579976

Abstract

The chemically stable but stereochemically flexible, non-toxic nature of zinc combined with its amphoteric properties has permitted it to orchestrate a number of zinc-binding motifs critical to life processes. For zinc enzymes, catalytic, cocatalytic, and structural zinc sites exist. DNA-binding proteins have zinc fingers, twists, and clusters exist.

摘要

锌具有化学稳定性但立体化学灵活性，其无毒特性与其两性性质相结合，使其能够构建许多对生命过程至关重要的锌结合基序。对于锌酶而言，存在催化、共催化和结构锌位点。DNA结合蛋白有锌指结构，还存在锌扭曲和锌簇。