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本文引用的文献

1
Serum cholesterol in young men and subsequent cardiovascular disease.年轻男性的血清胆固醇与随后的心血管疾病
N Engl J Med. 1993 Feb 4;328(5):313-8. doi: 10.1056/NEJM199302043280504.
2
Systematic underestimation of association between serum cholesterol concentration and ischaemic heart disease in observational studies: data from the BUPA study.观察性研究中血清胆固醇浓度与缺血性心脏病之间关联的系统性低估：来自保柏（BUPA）研究的数据
BMJ. 1994 Feb 5;308(6925):363-6. doi: 10.1136/bmj.308.6925.363.
3
By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?血清胆固醇浓度降低多少以及多快能降低缺血性心脏病的风险？
BMJ. 1994 Feb 5;308(6925):367-72. doi: 10.1136/bmj.308.6925.367.
4
The relationship of serum cholesterol to the incidence of cancer in Evans County, Georgia.
J Chronic Dis. 1980;33(5):311-32. doi: 10.1016/0021-9681(80)90026-0.
5
The Kockum study: twenty-two-year follow-up. Coronary heart disease in a population in the south of Sweden.科库姆研究：22年随访。瑞典南部人群中的冠心病。
Acta Med Scand. 1984;216(5):485-93.
6
Serum cholesterol and the incidence of cancer in a large cohort.一个大型队列中的血清胆固醇与癌症发病率
J Chronic Dis. 1986;39(11):861-70. doi: 10.1016/0021-9681(86)90034-2.
7
Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT).血清胆固醇与冠心病过早死亡风险之间的关系是连续且分级的吗？多重危险因素干预试验（MRFIT）356,222名初次筛查者的研究结果。
JAMA. 1986 Nov 28;256(20):2823-8.
8
Cholesterol and mortality. 30 years of follow-up from the Framingham study.胆固醇与死亡率。来自弗雷明汉心脏研究的30年随访
JAMA. 1987 Apr 24;257(16):2176-80. doi: 10.1001/jama.257.16.2176.
9
Site-specific analysis of total serum cholesterol and incident cancer in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study.在第一次全国健康与营养检查调查的流行病学随访研究中，对总血清胆固醇与新发癌症进行的特定部位分析。
Cancer Res. 1988 Jan 15;48(2):452-8.
10
Plasma cholesterol, coronary heart disease, and cancer in the Renfrew and Paisley survey.伦弗鲁和佩斯利调查中的血浆胆固醇、冠心病与癌症
BMJ. 1989 Apr 8;298(6678):920-4. doi: 10.1136/bmj.298.6678.920.

相对年轻时的总胆固醇浓度与死亡率：男性和女性有差异吗？

Total cholesterol concentration and mortality at a relatively young age: do men and women differ?

作者信息

Monique Verschuren W M, Kromhout D

机构信息

Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and Environmental Protection, Netherlands.

出版信息

BMJ. 1995 Sep 23;311(7008):779-83. doi: 10.1136/bmj.311.7008.779.

DOI:10.1136/bmj.311.7008.779
PMID:7580439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2550788/
Abstract

OBJECTIVE

To investigate the relation between total cholesterol concentration and mortality from coronary heart disease, cardiovascular diseases, non-cardiovascular causes, and all causes.

DESIGN

Population based cohort study.

SUBJECTS

23,000 men and 26,000 women aged 30-54 years examined between 1974 and 1980.

MAIN OUTCOME MEASURES

Mortality for the above mentioned end points for fifths of cholesterol distribution, and relative risks estimated by using Cox's proportional hazard (survival) analysis. Adjustment was made for age, smoking, systolic blood pressure, and body mass index.

RESULTS

Mortality from coronary heart disease in men was five times higher than that in women. A strong positive association between total cholesterol concentration and mortality from coronary heart disease and cardiovascular diseases was observed in both men and women. The relative risk for the highest compared with the lowest fifth of the cholesterol distribution was for mortality from coronary heart disease (3.0 (95% confidence interval 1.8 to 5.1) in men and 3.8 (1.1 to 13.1) in women) and for mortality from cardiovascular disease (2.8 (1.8 to 4.2) in men and 2.9 (1.4 to 6.0) in women). No increase of non-cardiovascular mortality at low cholesterol concentration was observed. All cause mortality was significantly higher in the highest compared with the lowest fifth of the cholesterol distribution: relative risk 1.6 (1.3 to 2.0) in men and 1.5 (1.1 to 1.9) in women.

CONCLUSION

Total cholesterol concentration is a strong predictor of mortality from coronary heart disease, cardiovascular diseases, and all causes in women as well as in men. Low cholesterol concentrations are not associated with increased mortality from non-cardiovascular causes.

摘要

目的

研究总胆固醇浓度与冠心病、心血管疾病、非心血管病因及所有病因导致的死亡率之间的关系。

设计

基于人群的队列研究。

研究对象

1974年至1980年间接受检查的23000名年龄在30 - 54岁的男性和26000名女性。

主要观察指标

胆固醇分布五分位数对应的上述终点的死亡率，以及使用Cox比例风险（生存）分析估计的相对风险。对年龄、吸烟、收缩压和体重指数进行了调整。

结果

男性冠心病死亡率是女性的五倍。在男性和女性中均观察到总胆固醇浓度与冠心病和心血管疾病死亡率之间存在强烈的正相关。胆固醇分布最高五分位数与最低五分位数相比，冠心病死亡率的相对风险为男性3.0（95%置信区间1.8至5.1），女性3.8（1.1至13.1）；心血管疾病死亡率的相对风险为男性2.8（1.8至4.2），女性2.9（1.4至6.0）。未观察到低胆固醇浓度时非心血管死亡率增加。胆固醇分布最高五分位数与最低五分位数相比，全因死亡率显著更高：男性相对风险为1.6（1.3至2.0），女性为1.5（1.1至1.9）。

结论

总胆固醇浓度是男性和女性冠心病、心血管疾病及所有病因导致死亡率的有力预测指标。低胆固醇浓度与非心血管病因导致的死亡率增加无关。