每日连续辐射剂量大小对大鼠血清蛋白及存活率的影响。
Effect of magnitude of daily continuous radiation dose on serum proteins and survival in rats.
作者信息
Chlebovská K, Chlebovský O, Praslicka M
出版信息
Folia Biol (Praha). 1978;24(1):51-8.
Changes in serum prealbumin, A1-macroglobulin, transferrin, and complement levels were studied in rats irradiated with daily doses of 100R (0.0258 C/kg), 200R (0.0516 C/kg) and 400R (0.1032 C/kg) until death. The daily dose of 100R applied for 39 days produced no changes in prealbumin and transferrin and a rise in the levels of A1-macroglobulin and complement. Shortly before death, i.e., between 39 and 44 days of irradiation, the levels of all four patients dropped. Daily doses of 200 and 400R caused a reduction in the levels of all four proteins since the very beginning. The LD 50 was 4 270R (1.1017 C/kg) at 100R/day, 4 060 R (1.0475 C/kg) at 200R/day, and 4 520 R (1.1342 C/kg) at 400R/day.
对每日接受100R（0.0258 C/kg）、200R（0.0516 C/kg）和400R（0.1032 C/kg）照射直至死亡的大鼠，研究其血清前白蛋白、α1-巨球蛋白、转铁蛋白和补体水平的变化。每日给予100R，持续39天，前白蛋白和转铁蛋白水平无变化，α1-巨球蛋白和补体水平升高。在死亡前不久，即照射39至44天之间，所有这四种物质的水平均下降。每日给予200R和400R从一开始就导致这四种蛋白质水平降低。每日100R时的半数致死剂量为4270R（1.1017 C/kg），每日200R时为4060 R（1.0475 C/kg），每日400R时为4520 R（1.1342 C/kg）。
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