Ricard-Blum S, Liance M, Houin R, Grimaud J A, Vuitton D A
CNRS URA 1459, Institut Pasteur de Lyon, France.
Parasite. 1995 Jun;2(2):113-8. doi: 10.1051/parasite/1995022113.
We report that covalent cross-linking of collagen molecules by pyridinoline increases significantly in liver in a murine model of alveolar echinococcosis. The highest amount of pyridinoline per collagen molecule (up to 3.5 fold the control values) is found in liver parasitic lesions. It is also increased, but to a far lesser extent, at distance from the fibrotic areas, in macroscopically normal zones of the liver, suggesting that the increase in mature collagen cross-linking occurring in the fibrogenesis due to Echinococcus multilocularis infection involves the whole liver. The comparison of these data with those we have obtained in another parasitic disease, murine schistosomiasis leading to a milder liver fibrosis, largely reversible following chemotherapy, supports a relationship between the liver pyridinoline level and the severity of liver fibrosis. Pyridinoline could be a tissular marker of chronic liver fibrosis in parasitic diseases.
我们报告称，在肺泡型棘球蚴病小鼠模型中，肝脏中吡啶啉介导的胶原分子共价交联显著增加。每个胶原分子中吡啶啉的含量最高（高达对照值的3.5倍）出现在肝脏寄生虫病变处。在远离纤维化区域的肝脏宏观正常区域，其含量也有所增加，但增幅要小得多，这表明多房棘球绦虫感染导致的肝纤维化过程中成熟胶原交联的增加涉及整个肝脏。将这些数据与我们在另一种寄生虫病——小鼠血吸虫病（导致较轻的肝纤维化，化疗后基本可逆）中获得的数据进行比较，支持了肝脏吡啶啉水平与肝纤维化严重程度之间的关系。吡啶啉可能是寄生虫病中慢性肝纤维化的组织标志物。
