Saraux A, de Saint Pierre V, Baron D, Valls I, Koreichi A, Youinou P, Le Goff P
Unit of Rheumatology, Brest University Medical School Hospital, France.
Br J Rheumatol. 1995 Oct;34(10):912-4. doi: 10.1093/rheumatology/34.10.912.
The aim of the present study was to evaluate the prevalence of antiperinuclear factor (APF) in patients with spondylarthropathy and the relationships between this autoantibody and a variety of clinical, radiological and serological findings. We conducted a retrospective review of the medical records of all patients first admitted to the Rheumatology Unit of the Brest University Medical School Hospital from 1 January 1986 to 31 December 1994, and who met the European Spondylarthropathy Study Group (ESSG) criteria at admission. Each patient had a standard battery of tests. Serum samples from 123 of 126 patients suffering from spondylarthropathy were examined for the presence of APF. Thirty-three patients (26.8%) had APF at a titre > or = 1/80. There were no significant relationships between various demographic, clinical or radiological characteristics and the presence of APF. However, the subgroup of APF-positive patients had a higher prevalence of both rheumatoid factors (RF), although not significant, and antikeratin antibody-positive serum than the rest. These results suggest that some patients had rheumatoid arthritis (RA) and three patients with APF > 1/100 and who were RF positive met ACR criteria for RA. APF should thus be used only as an additional serological marker in cases where clinical features suggest the association of spondylarthropathy with RA.
本研究的目的是评估脊柱关节病患者中抗核周因子（APF）的患病率，以及这种自身抗体与各种临床、放射学和血清学检查结果之间的关系。我们对1986年1月1日至1994年12月31日首次入住布雷斯特大学医学院医院风湿病科且入院时符合欧洲脊柱关节病研究组（ESSG）标准的所有患者的病历进行了回顾性分析。每位患者都进行了一系列标准检查。对126例脊柱关节病患者中的123例患者的血清样本进行了APF检测。33例患者（26.8%）的APF滴度≥1/80。各种人口统计学、临床或放射学特征与APF的存在之间无显著关系。然而，APF阳性患者亚组中类风湿因子（RF）（虽无统计学意义）和抗角蛋白抗体阳性血清的患病率均高于其余患者。这些结果表明，部分患者患有类风湿关节炎（RA），3例APF＞1/100且RF阳性的患者符合美国风湿病学会（ACR）的RA标准。因此，仅在临床特征提示脊柱关节病与RA相关的病例中，APF才可作为一项额外的血清学标志物使用。
