Tishler M, Maran R, Langevitz P, Livneh A, Gazit E, Gilburd B, Youinou P, Shoenfeld Y
Department of Rheumatology, Tel Aviv Souraski Medical Centre, Israel.
Rheumatol Int. 1997;17(4):141-3. doi: 10.1007/s002960050025.
The possible association between the presence of antiperinuclear factor (APF) and clinical and genetic parameters was investigated in 54 Israeli patients with rheumatoid arthritis (RA). Rheumatoid factor (RF) was detected in the sera of 43 patients (80%) and APF was positive in 33 (61%). No significant statistical differences were found in the presence of HLA-DR4 and/or DR1 between APF-positive and -negative patients. Furthermore, neither the Ritchie articular index nor the patient's functional class correlated with the presence of APF. The results of our study suggested that although Israeli patients have a different genetic background, the presence and behaviour of APF is similar to that of other Caucasian populations.
在54例以色列类风湿关节炎（RA）患者中，研究了抗核周因子（APF）的存在与临床及遗传参数之间可能的关联。43例患者（80%）血清中检测到类风湿因子（RF），33例（61%）APF呈阳性。APF阳性和阴性患者之间在HLA - DR4和/或DR1的存在方面未发现显著统计学差异。此外，Ritchie关节指数和患者功能分级均与APF的存在无关。我们的研究结果表明，尽管以色列患者有不同的遗传背景，但APF的存在和表现与其他白种人群相似。
