Mijiyawa M
Service de Rhumatologie du CHU-Tokoin de Lomé, Togo, West Africa.
Br J Rheumatol. 1995 Sep;34(9):843-6. doi: 10.1093/rheumatology/34.9.843.
A retrospective study was carried out to determine the semiological and aetiological profiles of gout in patients attending a hospital clinic in Lomé, Togo. Gout was diagnosed in 106 of the 3517 patients seen from October 1989 through October 1993. Clinical findings and hyperuricaemia were the basis for the diagnosis of gout in 88 patients. In the remaining 18 patients, monosodium urate crystals were demonstrated in synovial fluid in addition. One hundred and five patients were male. The mean age at disease onset was 45 yr and the mean duration of the disease was 8 yr. Twenty patients (19%) had tophi. None of the patients had a history of renal colic. The ankle, the knee and the first metatarsophalangeal joint were the joints most often affected. Sixty-three patients (59%) had a monoarticular involvement, whereas an oligo- or polyarticular involvement was observed in the remaining 43 patients. Twelve patients (11%) had a familial history of gout. Forty patients (38%) were obese and 78 (74%) were habitual drinkers. Forty-one patients (39%) had hypertension and 17 of them were under diuretic therapy. While more work is needed before drawing a definite conclusion, this study is in striking contradiction with the common belief that gout is exceedingly rare in Black Africa. The risk factors in Togo seem to be no different from those observed in Caucasians.
开展了一项回顾性研究,以确定多哥洛美一家医院门诊患者痛风的症状学和病因学特征。在1989年10月至1993年10月期间就诊的3517例患者中,有106例被诊断为痛风。88例患者根据临床症状和高尿酸血症诊断为痛风。其余18例患者,除上述症状外,还在滑液中发现了尿酸钠结晶。105例患者为男性。发病时的平均年龄为45岁,疾病的平均病程为8年。20例患者(19%)有痛风石。所有患者均无肾绞痛病史。踝关节、膝关节和第一跖趾关节是最常受累的关节。63例患者(59%)为单关节受累,其余43例患者为少关节或多关节受累。12例患者(11%)有痛风家族史。40例患者(38%)肥胖,78例患者(74%)有酗酒习惯。41例患者(39%)患有高血压,其中17例正在接受利尿剂治疗。虽然在得出明确结论之前还需要更多的研究,但这项研究与普遍认为痛风在黑非洲极为罕见的观点形成了鲜明的矛盾。多哥的风险因素似乎与高加索人观察到的风险因素没有差异。