Livingston D H, Mosenthal A C, Deitch E A
Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, USA.
New Horiz. 1995 May;3(2):257-66.
Multiple organ dysfunction syndrome (MODS) is the primary cause of death in patients admitted to ICUs. Despite the development of better resuscitation, more powerful antibiotics, and more sophisticated methods for organ support, our ability to rescue patients from established MODS has not improved significantly since the syndrome was first described two decades ago. Rapid advancements in molecular biology have begun to unravel some of the potential mechanisms behind the development of this syndrome, and have suggested many potential therapeutic approaches. To effectively use these new treatment options as they become available, it is necessary to have a clear understanding of how these therapies fit into the current theories on the pathophysiology of MODS. Thus, the goal of this article is to integrate what is new in our understanding of the development of MODS with current concepts regarding potential therapies of this complex and perplexing syndrome.
多器官功能障碍综合征（MODS）是入住重症监护病房（ICU）患者的主要死因。尽管在复苏、更强大的抗生素以及更先进的器官支持方法方面取得了进展，但自该综合征于二十年前首次被描述以来，我们从已确诊的MODS中挽救患者的能力并未显著提高。分子生物学的快速发展已开始揭示该综合征发生背后的一些潜在机制，并提出了许多潜在的治疗方法。为了在这些新的治疗选择出现时有效地加以利用，有必要清楚了解这些疗法如何融入当前关于MODS病理生理学的理论。因此，本文的目的是将我们对MODS发生的新认识与关于这一复杂且令人困惑的综合征潜在治疗方法的当前概念相结合。
