Rawe S E, Roth R H, Collins W F
J Neurosurg. 1977 Mar;46(3):350-7. doi: 10.3171/jns.1977.46.3.0350.
Alpha methyl tyrosine (AMT) or reserpine administered intravenously 24 hours before sacrificed in the nontraumatized cat resulted in significant reduction in tissue levels of norepinephrine (NE) tested at the T-5 spinal cord level. Phenoxybenzamine given 2 hours before sacrifice did not alter NE levels at T-5. Histological sections of spinal cord examined 1 hour after a 500-gm-cm trauma at the T-5 level in cats, pretreated 24 hours before trauma by a single dose of AMT or reserpine demonstrated no reduction of gray or white matter hemorrhages when compared tocontrols. In cats pretreated with phenoxybenzamine 2 hours before trauma there was a marked reduction of hemorrhages at 1 hour posttrauma when compared to controls. The animals treated with phenoxybenzamine had a 32% reduction of systemic blood pressure before trauma, demonstrated no pressor response to spinal cord trauma, and were severely hypotensive posttrauma. It is concluded that posttraumatic blood pressure has greater etiological significance in the pathogenesis of experimental spinal cord hemorrhages than tissue levels of NE.
在未受创伤的猫被处死前24小时静脉注射α-甲基酪氨酸（AMT）或利血平，导致在T-5脊髓水平检测到的去甲肾上腺素（NE）组织水平显著降低。在处死前2小时给予酚苄明并未改变T-5处的NE水平。在猫的T-5水平施加500克·厘米的创伤前24小时用单剂量的AMT或利血平预处理，创伤后1小时检查的脊髓组织学切片显示，与对照组相比，灰质或白质出血没有减少。在创伤前2小时用酚苄明预处理的猫，与对照组相比，创伤后1小时出血明显减少。用酚苄明治疗的动物在创伤前全身血压降低了32%，对脊髓创伤无升压反应，创伤后严重低血压。得出的结论是，创伤后血压在实验性脊髓出血的发病机制中比NE的组织水平具有更大的病因学意义。
