Wood R C
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555-1019, USA.
Cancer Lett. 1995 Sep 25;96(2):233-7. doi: 10.1016/0304-3835(95)03937-r.
A plasma-membrane-containing fraction isolated from Swiss mouse (3T3) fibroblasts was found to contain uridine diphosphate sugars and methyl-uridine diphosphate (mUDP) sugars. The synthesis of the mUDP sugars by membrane preparations of normal and transformed 3T3 cells occurred from the intrinsic membrane uridine-diphosphate sugars + methylenetetrahydrofolic acid. Compared to the normal 3T3 cells, the synthesis of mUDP sugars by the transformed 3T3 cells was reduced by 49%. It is proposed that the plasma-membrane-associated mUDP sugars may be essential for normal cell growth.
从瑞士小鼠（3T3）成纤维细胞中分离出的含质膜部分被发现含有尿苷二磷酸糖和甲基尿苷二磷酸（mUDP）糖。正常和转化的3T3细胞膜制剂由内在膜尿苷二磷酸糖+亚甲基四氢叶酸合成mUDP糖。与正常3T3细胞相比，转化的3T3细胞合成mUDP糖的量减少了49%。有人提出，与质膜相关的mUDP糖可能对正常细胞生长至关重要。
