Wood R C
Department of Microbiology and Immunology, University of Texas, Medical Branch, Galveston, 77555-1019, USA.
Cancer Lett. 1996 Feb 27;100(1-2):37-40. doi: 10.1016/0304-3835(95)04069-2.
A plasma membrane preparation from human amnion (WISH) cells contained uridine diphosphate sugars and methyl-uridine diphosphate (mUDP) sugars. The synthesis of mUDP-glucose, mUDP-mannose, and mUDP-fucose by the membrane preparation occurred when supplemented with uridine-5'-diphosphate-glucose and S-adenosyl-L-methionine. It is suggested that this newly recognized route for fucose biosynthesis might be employed by certain transformed cells, and may partly account for the methionine dependence of certain human tumors. Additionally, it is suggested that, in colon cancer, a deficiency of folic acid and methionine might affect mUDP-sugar biosynthesis rather than the methylation of DNA.
从人羊膜（WISH）细胞制备的质膜制剂中含有尿苷二磷酸糖和甲基尿苷二磷酸（mUDP）糖。当补充尿苷-5'-二磷酸葡萄糖和S-腺苷-L-甲硫氨酸时，该膜制剂可合成mUDP-葡萄糖、mUDP-甘露糖和mUDP-岩藻糖。有人提出，这种新发现的岩藻糖生物合成途径可能被某些转化细胞所采用，并且可能部分解释了某些人类肿瘤对甲硫氨酸的依赖性。此外，有人提出，在结肠癌中，叶酸和甲硫氨酸的缺乏可能影响mUDP-糖的生物合成，而不是DNA的甲基化。
