Atawodi S E, Preussmann R, Spiegelhalder B
Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre, Heidelberg, Germany.
Cancer Lett. 1995 Oct 20;97(1):1-6. doi: 10.1016/0304-3835(95)03941-o.
Ten popular brands of cigarettes on the Nigerian market were analyzed for tobacco-specific nitrosamines (TSNA) in tobacco and in mainstream smoke, as well as nitrate in tobacco. TSNA was analyzed using a gas chromatography/thermal energy analyzer (GC-TEA), while nitrate was determined spectrophotometrically as nitrite following on-line reduction with copper, diozatization with sulfanilamide and coupling with N-(1-naphthyl) ethylene diamine to form an azo dye. In mainstream smoke, the concentration of NNN, NAB/NAT and NNK were respectively, between 8 and 90 ng, 10 and 65 ng, and between 15 and 72 ng/cigarette. Preformed NNN ranged between 64 and 565 ng/cigarette, while preformed NAB/NAT and NNK ranged respectively from 109 to 476 ng/cigarette, and from 55 to 317 ng/cigarette. Nitrate levels ranged between 1.5 and 6.1 mg/g tobacco. In general, the results indicate that the TSNA content of Nigerian cigarettes are within the range found for European and American cigarettes.
对尼日利亚市场上十种流行品牌香烟的烟草及主流烟雾中的烟草特有亚硝胺（TSNA）以及烟草中的硝酸盐进行了分析。TSNA采用气相色谱/热能分析仪（GC-TEA）进行分析，而硝酸盐则通过在线用铜还原、用磺胺进行重氮化以及与N-（1-萘基）乙二胺偶联形成偶氮染料后，以亚硝酸盐形式用分光光度法测定。在主流烟雾中，NNN、NAB/NAT和NNK的浓度分别为每支香烟8至90纳克、10至65纳克以及15至72纳克。预制NNN的含量为每支香烟64至565纳克，而预制NAB/NAT和NNK的含量分别为每支香烟109至476纳克以及55至317纳克。硝酸盐含量在每克烟草1.5至6.1毫克之间。总体而言，结果表明尼日利亚香烟的TSNA含量在欧美香烟的含量范围内。
