Kuroda M, Mimaki Y, Sashida Y, Hirano T, Oka K, Dobashi A
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Chem Pharm Bull (Tokyo). 1995 Jul;43(7):1257-9. doi: 10.1248/cpb.43.1257.
A novel 16,23-epoxy-5 beta-cholestane triglycoside (1) was isolated from the bulbs of Ornithogalum saundersiae (Liliaceae). The structure was determined by extensive spectroscopic analysis. The conformation of the E-ring part of 1 was studied through molecular mechanics and molecular dynamics calculation methods. Compound 1 potently inhibited proliferation of peripheral blood lymphocytes provided from a chronic renal failure patient without causing any cytotoxicity in the lymphocytes and HL-60 human leukemia cells.
从虎眼万年青（百合科）的鳞茎中分离出一种新型的16,23-环氧-5β-胆甾烷三糖苷（1）。通过广泛的光谱分析确定了其结构。通过分子力学和分子动力学计算方法研究了1中E环部分的构象。化合物1能有效抑制一名慢性肾衰竭患者外周血淋巴细胞的增殖，且对淋巴细胞和HL-60人白血病细胞均无任何细胞毒性。
