Watanabe M, Suzuki K, Kodama S, Sugahara T
Department of Health Sciences, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
Carcinogenesis. 1995 Oct;16(10):2373-80. doi: 10.1093/carcin/16.10.2373.
We investigated the heat-sensitivity of normal human cells and cells derived from human cancers (cancer cells) heated at 43 degrees C under different culture conditions. Primary human cells which keep in contact with each other show heat resistance, but cancer cells do not. This does not correlate with the total cellular amount of heat shock protein 72, but rather with accumulation of the protein in the nucleus after heating.
我们研究了在不同培养条件下，正常人类细胞和源自人类癌症的细胞（癌细胞）在43摄氏度加热时的热敏感性。相互接触的原代人类细胞表现出耐热性，但癌细胞则不然。这与热休克蛋白72的细胞总量无关，而是与加热后该蛋白在细胞核中的积累有关。
