O'Brien T J, Gates P
Department of Clinical Neuroscience, St. Vincent's Hospital, Melbourne.
Clin Exp Neurol. 1994;31:52-60.
Isaac's syndrome is an uncommon, but distressing, condition of spontaneous abnormal muscle activity caused by neuronal hyperexcitability possibly due to damage to slow potassium channels. The underlying aetiology may be peripheral nerve damage from a wide variety of causes, including autoimmune disease. We report a case that failed to respond to carbamazepine or phenytoin but responded dramatically to valproic acid. Thus, valproic acid may be an effective treatment for Isaac's syndrome where these other drugs have failed.
艾萨克综合征是一种罕见但令人痛苦的疾病，由神经元过度兴奋引起自发异常肌肉活动，可能是由于慢钾通道受损所致。潜在病因可能是多种原因导致的周围神经损伤，包括自身免疫性疾病。我们报告一例对卡马西平或苯妥英钠治疗无效，但对丙戊酸有显著反应的病例。因此，在其他药物治疗无效的情况下，丙戊酸可能是治疗艾萨克综合征的有效药物。
