Sim J G, Kim E C, Seo J K
Department of Pediatrics, Seoul National University College of Medicine, Korea.
Clin Pediatr (Phila). 1995 Sep;34(9):458-62. doi: 10.1177/000992289503400901.
The aim of this study was to evaluate the diagnostic accuracy of serologic tests and to verify whether specific IgG antibody can be used in the diagnosis of Helicobacter pylori infection in children without endoscopy. Serologic and endoscopic examinations were performed in 310 children (1 month-15 years) with gastrointestinal symptoms. Serologic outcomes were compared with the results of rapid urease test, histologic examination, and culture. The prevalence of H. pylori infection was 21.0% and the seropositivity of H. pylori was 24.2% in these symptomatic children. Serologic examination for diagnosis of H. pylori showed a sensitivity of 94.9% and a specificity of 92.4%, diagnostic reliability equal to the rapid urease test and histologic examination in children. The serum IgG test is a useful tool for the diagnosis of H. pylori infection, especially in children.
本研究的目的是评估血清学检测的诊断准确性，并验证特异性IgG抗体是否可用于在无内镜检查的情况下诊断儿童幽门螺杆菌感染。对310名有胃肠道症状的儿童（1个月至15岁）进行了血清学和内镜检查。将血清学结果与快速尿素酶试验、组织学检查和培养结果进行比较。在这些有症状的儿童中，幽门螺杆菌感染率为21.0%，幽门螺杆菌血清阳性率为24.2%。用于诊断幽门螺杆菌的血清学检查显示敏感性为94.9%，特异性为92.4%，其诊断可靠性与儿童快速尿素酶试验和组织学检查相当。血清IgG检测是诊断幽门螺杆菌感染的有用工具，尤其是在儿童中。
