Milsom I, Andersson K, Jonasson K, Lindstedt G, Rybo G
Department of Obstetrics & Gynecology, East Hospital, Göteborg, Sweden.
Contraception. 1995 Sep;52(3):175-9. doi: 10.1016/0010-7824(95)00163-5.
The influence of the Gyne-T 380S intrauterine contraceptive device (IUD) on menstrual blood loss (MBL) and iron status (hemoglobin, hematocrit, red cell count and indices, and serum ferritin) was evaluated. MBL was determined objectively by the alkaline hematin method in 18 women (mean age 37.1 +/- 1.6 yr, range 22-46 yr) before and 3, 6 and 12 months after insertion of a Gyne-T 380S IUD. MBL prior to IUD insertion was 59 +/- 8 ml and increased to 91 +/- 11 ml (p < 0.01) 3 months after insertion. MBL then remained largely unchanged during the remainder of the observation period (6 months, 94 +/- 12 ml; 12 months, 92 +/- 13 ml). The percentage increase in MBL at the respective measurement points ranged between 54 and 59% which is comparable with previous reports regarding the increase in MBL associated with the use of a copper IUD. There were no significant changes recorded in iron status parameters during the 12-month observation period following IUD insertion. Based on the results of the present study, women from developed countries apparently tolerate an increased MBL of approximately 55% without developing iron deficiency anemia. Iron stores were unchanged indicating an adequate adaptive increase in intestinal iron absorption.
评估了Gyne-T 380S宫内节育器（IUD）对月经量（MBL）和铁状态（血红蛋白、血细胞比容、红细胞计数及指数以及血清铁蛋白）的影响。采用碱性正铁血红素法对18名女性（平均年龄37.1±1.6岁，范围22 - 46岁）在插入Gyne-T 380S宫内节育器前以及插入后3、6和12个月时的月经量进行了客观测定。宫内节育器插入前月经量为59±8毫升，插入后3个月增加至91±11毫升（p<0.01）。随后在观察期剩余时间内月经量基本保持不变（6个月时为94±12毫升；12个月时为92±13毫升）。各测量点月经量增加的百分比在54%至59%之间，这与先前关于使用铜宫内节育器导致月经量增加的报道相当。在宫内节育器插入后的12个月观察期内，铁状态参数未记录到显著变化。基于本研究结果，发达国家的女性显然能够耐受约55%的月经量增加而不发生缺铁性贫血。铁储备未变，表明肠道铁吸收有足够的适应性增加。
