Healy M J, Walshe K, Weir D G, Keane C T, Speekenbrink A B, O'Moore R R
Department of Biochemistry, Dublin, Ireland.
Dig Dis Sci. 1995 Nov;40(11):2456-9. doi: 10.1007/BF02063254.
Lipid malabsorption is a common clinical manifestation of small bowel bacterial overgrowth. Its pathogenesis, however, remains controversial. Bacteroides melaninogenicus ssp. intermedius, an anaerobic bacterium, is commonly isolated from the upper bowel of patients with small intestinal bacterial overgrowth. The effects of a culture supernate of this organism and deoxycholate, an unconjugated bile salt, on intestinal oleic acid absorption were examined using a rat closed-loop model. The supernatant reduced the in vitro uptake of oleic acid by 19% (P< 0.001). Deoxycholate did not significantly reduce the lipid absorption. Combined supernate and deoxycholate did not have an additive effect on absorption of oleic acid. We conclude that anaerobic bacterial products may contribute to the malabsorption of lipid in the setting of bacterial overgrowth of the small bowel.
脂质吸收不良是小肠细菌过度生长的常见临床表现。然而，其发病机制仍存在争议。中间型产黑色素拟杆菌是一种厌氧菌，常见于小肠细菌过度生长患者的上消化道。使用大鼠闭环模型研究了该菌的培养上清液和未结合胆汁盐脱氧胆酸盐对肠道油酸吸收的影响。上清液使油酸的体外摄取减少了19%（P<0.001）。脱氧胆酸盐并未显著降低脂质吸收。上清液和脱氧胆酸盐联合使用对油酸吸收没有相加作用。我们得出结论，在小肠细菌过度生长的情况下，厌氧细菌产物可能导致脂质吸收不良。
