Brady K T, Sonne S, Randall C L, Adinoff B, Malcolm R
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29426, USA.
Drug Alcohol Depend. 1995 Jul;39(1):69-71. doi: 10.1016/0376-8716(95)01128-l.
In order to assess differences between cocaine dependence alone and cocaine dependence complicated by alcohol abuse, 34 subjects who met DSM-III-R criteria for alcohol abuse and cocaine dependence (COC-ETOH group) were compared with 39 subjects who met criteria for cocaine dependence only (COC-only group) with regard to demographics, substance use, and psychopathology. There were no differences between groups in age, race, employment or socio-economic status. The baseline depression and global severity scores in the COC-ETOH group were significantly higher than in the COC-only group. The COC-ETOH group was significantly more likely to experience a paranoid psychosis with cocaine use and significantly more likely to have abused additional substances in the month prior to study entry. The COC-ETOH group also attended significantly fewer medication management sessions during the 12-week trial. There were no differences between groups in the type or frequency of Axis 1 or Axis II disorders.
为了评估单纯可卡因依赖与合并酒精滥用的可卡因依赖之间的差异，将34名符合DSM-III-R酒精滥用和可卡因依赖标准的受试者（COC-ETOH组）与39名仅符合可卡因依赖标准的受试者（仅COC组）在人口统计学、物质使用和精神病理学方面进行了比较。两组在年龄、种族、就业或社会经济地位方面没有差异。COC-ETOH组的基线抑郁和总体严重程度评分显著高于仅COC组。COC-ETOH组在使用可卡因时更易出现偏执性精神病，且在研究入组前一个月更易滥用其他物质。在为期12周的试验中，COC-ETOH组参加药物管理疗程的次数也显著较少。两组在轴I或轴II障碍的类型或频率上没有差异。
