Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-3944, USA.
Am J Addict. 2012 Jan-Feb;21(1):47-54. doi: 10.1111/j.1521-0391.2011.00185.x. Epub 2011 Nov 18.
The use of quality of life (QOL) measures in substance abuse treatment research is important because it may lead to a broader understanding of patients' health status and effects of interventions. Despite the high rates of comorbid cocaine and alcohol use disorders, little is known about the QOL of this population, and even less about the impact of an efficacious behavioral treatment, contingency management (CM), on QOL. In this study, data from three clinical trials were retrospectively analyzed to examine QOL in outpatient cocaine abusers with and without alcohol dependence (AD) and the impact of CM on QOL over time as a function of AD status. Patients were randomized to standard care (n = 115) or standard care plus CM (n = 278) for 12 weeks. QOL was assessed at baseline and Months 1, 3, 6, and 9. At treatment initiation, AD patients had lower QOL total scores and they scored lower on several subscale scores than those without AD. CM treatment was associated with improvement in QOL regardless of AD status. These data suggest that CM produces benefits that go beyond substance abuse outcomes, and they support the use of QOL indexes to capture information related to treatment outcomes.
在物质滥用治疗研究中使用生活质量(QOL)测量很重要,因为它可能会更全面地了解患者的健康状况和干预措施的效果。尽管可卡因和酒精使用障碍的共病率很高,但对该人群的 QOL 知之甚少,更不知道有效的行为治疗—— contingencymanagement(CM)——对 QOL 的影响。在这项研究中,对三项临床试验的数据进行了回顾性分析,以研究门诊可卡因滥用者中有无酒精依赖(AD)的 QOL,并根据 AD 状况,研究 CM 对 QOL 的影响随时间的变化。患者被随机分配到标准护理(n=115)或标准护理加 CM(n=278)治疗 12 周。在基线和第 1、3、6 和 9 个月评估 QOL。在治疗开始时,AD 患者的 QOL 总分较低,在几个子量表上的得分也低于没有 AD 的患者。CM 治疗与 QOL 的改善有关,无论 AD 状况如何。这些数据表明,CM 产生的益处不仅限于物质滥用结果,并且支持使用 QOL 指标来获取与治疗结果相关的信息。