Brown N A, Holt D, Webb M
Toxicol Lett. 1984 Jul;22(1):93-100. doi: 10.1016/0378-4274(84)90051-1.
Intraperitoneal (i.p.) administration of methoxyacetic acid (MAA) to rats on Day 8, 10, 12 or 14 of pregnancy was embryolethal and teratogenic. Skeletal anomalies, hydrocephalus and dilatation of the kidney pelvis were the most common malformations. Embryonic response to MAA varied with gestational age and with dosage (0.1 to 2.5 mmol/kg). These actions are similar to those previously reported for 2-methoxyethanol (ME) and dimethoxyethyl phthalate (DMEP). Embryos were also examined on Day 12, 48 h following i.p. administration of 2.5 mmol/kg MAA. Abnormalities were comparable to those previously observed following MAA treatment of rat conceptuses in culture. These data support the conclusion that MAA is the proximal teratogenic metabolite of ME and DMEP.
在妊娠第8、10、12或14天给大鼠腹腔注射甲氧基乙酸（MAA）具有胚胎致死性和致畸性。骨骼异常、脑积水和肾盂扩张是最常见的畸形。胚胎对MAA的反应随胎龄和剂量（0.1至2.5 mmol/kg）而变化。这些作用与先前报道的2-甲氧基乙醇（ME）和邻苯二甲酸二甲氧基乙酯（DMEP）的作用相似。在腹腔注射2.5 mmol/kg MAA后48小时的第12天也对胚胎进行了检查。异常情况与先前在培养中用MAA处理大鼠胚胎后观察到的情况相当。这些数据支持以下结论：MAA是ME和DMEP的近端致畸代谢产物。
