在健康受试者中，静脉输注硝酸甘油后，内皮素-1的血浆水平不会立即改变。

Venous plasma levels of endothelin-1 are not altered immediately after nitroglycerin infusion in healthy subjects.

作者信息

Thomsen L L, Iversen H K, Emmeluth C, Bie P

机构信息

Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.

出版信息

Eur J Clin Pharmacol. 1995;48(2):139-42. doi: 10.1007/BF00192739.

DOI:10.1007/BF00192739

PMID:7589028

Abstract

Endothelin-1 and nitric oxide play an important regulatory role in the control of vascular smooth muscle tone. Nitroglycerin (NTG), a nitric oxide donating drug, may inhibit endothelin production. In this double-blind placebo-controlled crossover study, plasma levels of endothelin-1 were measured before and immediately (5-30 s) after 80 min infusion of NTG (glyceryl trinitrate) or saline in 12 healthy subjects. On two different days separated by at least 1 week, NTG in four different doses, 0.015, 0.25, 1.0, and 2.0 micrograms. kg-1. min-1, or placebo (isotonic saline) was infused successively for 20 min each dose. During the infusion blood pressure and heart rate were measured. NTG infusion significantly decreased systolic blood pressure from 112.4 to 103.4 mmHg and pulse pressure from 39.3 to 29.5 mmHg. Heart rate increased from 62.7 to 73.1 beats. min-1. No changes in endothelin-1 plasma levels were induced by NTG infusion (2.4 pg.ml-1 before NTG vs. 2.7 pg.ml-1 after NTG) and placebo infusion also did not affect plasma endothelin-1. It is concluded that venous plasma levels of endothelin-1 are not altered immediately after NTG infusion.

摘要

内皮素 -1 和一氧化氮在控制血管平滑肌张力方面发挥着重要的调节作用。硝酸甘油（NTG）是一种释放一氧化氮的药物，可能会抑制内皮素的产生。在这项双盲、安慰剂对照的交叉研究中，对 12 名健康受试者在输注 NTG（硝酸甘油）或生理盐水 80 分钟之前及之后立即（5 - 30 秒）测量血浆内皮素 -1 水平。在至少间隔 1 周的两个不同日子里，依次以四种不同剂量，即 0.015、0.25、1.0 和 2.0 微克·千克⁻¹·分钟⁻¹ 的 NTG 或安慰剂（等渗盐水）进行输注，每种剂量输注 20 分钟。在输注过程中测量血压和心率。输注 NTG 后收缩压从 112.4 显著降至 103.4 mmHg，脉压从 39.3 降至 29.5 mmHg。心率从 62.7 次·分钟⁻¹ 增加到 73.1 次·分钟⁻¹。输注 NTG 未引起内皮素 -1 血浆水平的变化（NTG 输注前为 2.4 pg·ml⁻¹，输注后为 2.7 pg·ml⁻¹），安慰剂输注也未影响血浆内皮素 -1。得出的结论是，输注 NTG 后静脉血浆内皮素 -1 水平不会立即改变。