Maguire H C, Holmes E, Hollyer J, Strangeways J E, Foster P, Holliman R E, Stanwell-Smith R
Public Health Laboratory, St George's Hospital, London.
Epidemiol Infect. 1995 Oct;115(2):279-87. doi: 10.1017/s0950268800058404.
An outbreak of cryptosporidiosis which affected 44 people in January and February 1991 was identified through local surveillance at a South London Public Health Laboratory. Preliminary enquiries revealed that more than half the patients were adult and that there were no common factors other than geographical association. A case-control study showed a significant association between illness and consumption of tap water supplied by a particular water company, as well as a dose response effect. There were no apparent breaches or irregularities in the water distribution system and no indication of a problem through routine monitoring indices. This incident demonstrates the problems of establishing the source of cryptosporidiosis outbreaks in the absence of evidence of environmental abnormality, as well as possibly indicating that water conforming to current treatment standards may occasionally contain sufficient numbers of Cryptosporidium oocysts to cause sporadic cases or clusters.
1991年1月至2月间，伦敦南部一家公共卫生实验室通过当地监测确认了一起隐孢子虫病暴发事件，该事件影响了44人。初步调查显示，半数以上患者为成年人，除地域关联外没有其他共同因素。一项病例对照研究表明，疾病与特定自来水公司供应的自来水消费之间存在显著关联，以及剂量反应效应。供水系统没有明显的违规或异常情况，常规监测指标也没有显示出问题。这一事件表明，在缺乏环境异常证据的情况下，确定隐孢子虫病暴发源头存在问题，同时也可能表明，符合当前处理标准的水偶尔可能含有足够数量的隐孢子虫卵囊，从而导致散发病例或聚集性病例。
