McMillan D C, Leen E, Smith J, Sturgeon C, Preston T, Cooke T G, McArdle C S
University Department of Surgery, Royal Infirmary, Glasgow, UK.
Eur J Surg Oncol. 1995 Oct;21(5):531-4. doi: 10.1016/s0748-7983(95)97157-2.
The regulation of acute phase protein production and the relationship of the acute phase protein response to tumour growth was examined in colorectal cancer patients (n = 9). Ibuprofen (1200 mg/d) was administered for 8-11 days. Following ibuprofen administration there were reductions in circulating concentrations of C-reactive protein (P = 0.01), interleukin-6 (P = 0.06), cortisol (P = 0.04) and also in the platelet count (P = 0.01). There was no significant change in albumin, insulin and carcinoembryonic antigen. These results indicate that ibuprofen administered over a prolonged period substantially reduces acute protein production via its effect on interleukin-6 and cortisol. It remains to be determined whether ibuprofen is useful in moderating tumour growth in colorectal cancer patients.
对9名结直肠癌患者研究了急性期蛋白产生的调节以及急性期蛋白反应与肿瘤生长的关系。给予布洛芬（1200毫克/天），持续8至11天。服用布洛芬后，C反应蛋白的循环浓度降低（P = 0.01），白细胞介素-6降低（P = 0.06），皮质醇降低（P = 0.04），血小板计数也降低（P = 0.01）。白蛋白、胰岛素和癌胚抗原无显著变化。这些结果表明，长期服用布洛芬可通过其对白细胞介素-6和皮质醇的作用，大幅降低急性期蛋白的产生。布洛芬对结直肠癌患者肿瘤生长的调节作用还有待确定。
