非小细胞肺癌中体重减轻与白细胞介素6的关系。
The relationship between weight loss and interleukin 6 in non-small-cell lung cancer.
作者信息
Scott H R, McMillan D C, Crilly A, McArdle C S, Milroy R
机构信息
Department of Respiratory Medicine, Stobhill NHS Trust, Glasgow, UK.
出版信息
Br J Cancer. 1996 Jun;73(12):1560-2. doi: 10.1038/bjc.1996.294.
Abstract
Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and platelets (P < 0.01) in the weight-losing group. Moreover, there was a statistically significant correlation (r = 0.785, P < 0.001) between interleukin 6 and C-reactive protein concentrations. These results are consistent with interleukin 6 and the acute phase response promoting weight loss in NSCLC.
摘要
在体重减轻（>5%）和未体重减轻的非小细胞肺癌（NSCLC）患者（n = 21）中，检测了炎症反应标志物白细胞介素6、C反应蛋白、白蛋白和全血细胞计数。体重减轻组患者循环C反应蛋白（P < 0.001）、白细胞介素6（P < 0.01）和血小板（P < 0.01）显著增加。此外，白细胞介素6与C反应蛋白浓度之间存在统计学显著相关性（r = 0.785，P < 0.001）。这些结果与白细胞介素6和急性期反应促进NSCLC患者体重减轻一致。
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