Preston T, Fearon K C, McMillan D C, Winstanley F P, Slater C, Shenkin A, Carter D C
Isotope Biochemistry Laboratory, Scottish Universities Research and Reactor Centre, Glasgow, UK.
Br J Surg. 1995 Feb;82(2):229-34. doi: 10.1002/bjs.1800820233.
The aim of this study was to determine whether administration of the non-steroidal anti-inflammatory agent ibuprofen might attenuate the acute-phase response in patients with colonic cancer. Cytokines and acute-phase proteins were measured before administration of ibuprofen and again 3 days later, when protein synthesis was measured using 15N-glycine. In patients with cancer, ibuprofen caused a significant reduction in the plasma concentration of all five acute-phase proteins studied. Although interleukin 6 levels were raised, they did not change following administration of ibuprofen. Unlike the situation in patients with cancer who did not receive ibuprofen, whole-body protein kinetics were similar to those of control subjects in patients with cancer who received ibuprofen. Whether or not ibuprofen had been administered, non-export hepatic protein synthesis rates were significantly lower in patients with than in those without cancer. These results suggest that short-term administration of ibuprofen can attenuate accelerated whole-body protein kinetics and the acute-phase response in patients with advanced cancer.
本研究的目的是确定给予非甾体抗炎药布洛芬是否可能减轻结肠癌患者的急性期反应。在给予布洛芬之前以及3天后再次测量细胞因子和急性期蛋白，此时使用15N-甘氨酸测量蛋白质合成。在癌症患者中，布洛芬使所研究的所有五种急性期蛋白的血浆浓度显著降低。虽然白细胞介素6水平升高，但给予布洛芬后其并未改变。与未接受布洛芬的癌症患者的情况不同，接受布洛芬的癌症患者的全身蛋白质动力学与对照受试者相似。无论是否给予布洛芬，癌症患者的非输出性肝脏蛋白质合成率均显著低于无癌症患者。这些结果表明，短期给予布洛芬可减轻晚期癌症患者加速的全身蛋白质动力学和急性期反应。
