Kodama H, Fukuda J, Karube H, Matsui T, Shimizu Y, Tanaka T
Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan.
Fertil Steril. 1995 Dec;64(6):1207-9. doi: 10.1016/s0015-0282(16)57987-4.
To investigate whether a patient with ovarian hyperstimulation syndrome (OHSS) demonstrated characteristic changes in the blood hemostatic markers before she developed thromboembolism.
Patients with OHSS had blood drawn to determine hemostatic markers and related factors.
Twenty-three OHSS patients, including a case complicated with thromboembolism.
The IVF-ET program of the Department of Obstetrics and Gynecology, The University of Akita, School of Medicine.
Blood hemostatic markers and related factors.
The patient with thromboembolism demonstrated marked leukocytosis and higher levels of activation in the blood markers related to fibrinolytic system, such as alpha 2 plasmin inhibitor, plasmin-alpha 2 antiplasmin complexes, and D-dimers, before the onset of this episode.
Marked leukocytosis and higher levels of activation of the fibrinolytic system may be the signs of imminent thromboembolism in OHSS patients.
调查卵巢过度刺激综合征（OHSS）患者在发生血栓栓塞之前，其血液止血标志物是否有特征性变化。
对OHSS患者进行采血，以测定止血标志物及相关因素。
23例OHSS患者，包括1例合并血栓栓塞的病例。
秋田大学医学院妇产科的体外受精-胚胎移植项目。
血液止血标志物及相关因素。
发生血栓栓塞的患者在此次发作前表现出明显的白细胞增多，以及与纤溶系统相关的血液标志物（如α2纤溶酶抑制剂、纤溶酶-α2抗纤溶酶复合物和D-二聚体）的更高水平激活。
明显的白细胞增多和纤溶系统的更高水平激活可能是OHSS患者即将发生血栓栓塞的迹象。
