Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation syndrome who actually developed thromboembolism.

OBJECTIVE

To investigate whether a patient with ovarian hyperstimulation syndrome (OHSS) demonstrated characteristic changes in the blood hemostatic markers before she developed thromboembolism.

DESIGN

Patients with OHSS had blood drawn to determine hemostatic markers and related factors.

PATIENTS

Twenty-three OHSS patients, including a case complicated with thromboembolism.

SETTING

The IVF-ET program of the Department of Obstetrics and Gynecology, The University of Akita, School of Medicine.

MAIN OUTCOME MEASURES

Blood hemostatic markers and related factors.

RESULTS

The patient with thromboembolism demonstrated marked leukocytosis and higher levels of activation in the blood markers related to fibrinolytic system, such as alpha 2 plasmin inhibitor, plasmin-alpha 2 antiplasmin complexes, and D-dimers, before the onset of this episode.

CONCLUSION

Marked leukocytosis and higher levels of activation of the fibrinolytic system may be the signs of imminent thromboembolism in OHSS patients.