De Luca F, Arrigo T, Di Benedetto A, Tedeschi A, Sferlazzas C, Crisafulli G, Di Cesare E, Romano G, Magazzù G, Cucinotta D
Institute of Pediatrics, University of Messina, Italy.
Horm Res. 1995;44(2):45-50. doi: 10.1159/000184591.
Plasma glucose and insulin responses to oral glucose load were investigated and reinvestigated approximately 4 years later in 29 cystic fibrosis children and adolescents with initially normal fasting blood glucose levels. Patients' clinical status was evaluated at the time of both oral glucose tolerance tests. With respect to the basal test, the second one elicited blunted insulin responses and enhanced glycemic levels. Moreover, the prevalence of patients with diabetic glucose tolerance was significantly increased at the second evaluation and insulin secretion was markedly reduced in these patients. Deterioration of glucose tolerance and/or of insulin secretion over time was never accompanied by a significant worsening of clinical and/or nutritional status. In conclusion, in cystic fibrosis subjects with fasting euglycemia (a) both insulin secretion and glucose tolerance deteriorate during a 4-year follow-up, (b) an insulin secretion decrease is more evident in patients who develop diabetic glucose tolerance and (c) these metabolic changes are not significantly linked to a worsening of either nutritional or clinical parameters, even in the patients who develop diabetic glucose tolerance.
对29名空腹血糖水平最初正常的囊性纤维化儿童和青少年进行了血浆葡萄糖和胰岛素对口服葡萄糖负荷的反应研究，并在大约4年后进行了重新研究。在两次口服葡萄糖耐量试验时均评估了患者的临床状况。关于基础试验，第二次试验引发的胰岛素反应减弱，血糖水平升高。此外，在第二次评估时，糖尿病糖耐量患者的患病率显著增加，这些患者的胰岛素分泌明显减少。随着时间的推移，糖耐量和/或胰岛素分泌的恶化从未伴随着临床和/或营养状况的显著恶化。总之，在空腹血糖正常的囊性纤维化患者中，（a）在4年随访期间胰岛素分泌和糖耐量均恶化，（b）在出现糖尿病糖耐量的患者中胰岛素分泌减少更为明显，（c）即使在出现糖尿病糖耐量的患者中，这些代谢变化与营养或临床参数的恶化也没有显著关联。
