Johns D W, Ayers C R, Carey R M
J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):582-7. doi: 10.1097/00005344-198407000-00005.
Acute bromocriptine administration reduced sitting and standing blood pressure and produced severe orthostatic hypotension in 12 normal subjects. Concomitantly, there was an increase in venous distensibility and basal blood flow, and a decrease in peripheral vascular resistance, as determined by forearm plethysmography. After administration of bromocriptine, plasma norepinephrine concentration decreased. Bromocriptine lowers blood pressure by dilating arterioles and veins, at least in part by means of dopaminergic inhibition of sympathetic nervous system activity.
对12名正常受试者急性给予溴隐亭可降低其坐位和立位血压，并导致严重的直立性低血压。同时，通过前臂体积描记法测定发现，静脉扩张性和基础血流量增加，外周血管阻力降低。给予溴隐亭后，血浆去甲肾上腺素浓度降低。溴隐亭通过扩张小动脉和静脉来降低血压，至少部分是通过多巴胺能抑制交感神经系统活动实现的。
