Borgdorff M W, Barongo L R, Klokke A H, Newell J N, Senkoro K P, Velema J P, Gabone R M
National Institute for Medical Research, Mwanza, Tanzania.
Genitourin Med. 1995 Aug;71(4):212-5. doi: 10.1136/sti.71.4.212.
To determine HIV-1 incidence and HIV-1 associated mortality in a prospective cohort study. To determine whether the cohort is suitable for studies aiming to determine the impact of interventions on HIV-1 incidence.
The study population was a cohort of 1772 urban factory workers (1478 men and 294 women) in northwest Tanzania. The study took place from October 1991 to September 1993. Outcome measures were HIV-1 seroconversion and death.
HIV-1 incidence was 1.2 (95% CI 0.7-2.0) per 100 person-years (pyr). Crude annual mortality was 4.9 per 100 pyr in those with and 0.3 in those without HIV-1 infection, giving an age and sex adjusted mortality ratio of 12.9 (95% CI 5.4-30.7). Of all deaths, 62% were attributable to HIV-1 infection.
HIV-1 infection was a major public health problem, being the major cause of death in this adult population. At an HIV-1 incidence of 1.2 per 100 pyr, a large cohort size would be required to evaluate the impact of interventions on HIV-1 incidence.
在一项前瞻性队列研究中确定HIV-1发病率及与HIV-1相关的死亡率。确定该队列是否适合用于旨在确定干预措施对HIV-1发病率影响的研究。
研究人群为坦桑尼亚西北部城市的1772名工厂工人队列（1478名男性和294名女性）。研究于1991年10月至1993年9月进行。观察指标为HIV-1血清阳转和死亡。
HIV-1发病率为每100人年1.2例（95%可信区间0.7 - 2.0）。HIV-1感染者的粗年死亡率为每100人年4.9例，未感染HIV-1者为每100人年0.3例，年龄和性别校正后的死亡率比值为12.9（95%可信区间5.4 - 30.7）。在所有死亡病例中，62%归因于HIV-1感染。
HIV-1感染是一个主要的公共卫生问题，是该成年人群死亡的主要原因。在HIV-1发病率为每100人年1.2例的情况下，需要一个大规模队列来评估干预措施对HIV-1发病率的影响。
