Turchany J M, Aley S B, Gillin F D
Division of Infectious Diseases, University of California at San Diego 92103-8416, USA.
Infect Immun. 1995 Nov;63(11):4550-2. doi: 10.1128/iai.63.11.4550-4552.1995.
Human and bovine lactoferrins and their derived N-terminal peptides were giardicidal in vitro. Fe3+, but not Fe2+, protected trophozoites from both native lactoferrin and peptides, although the latter lack iron-binding sites. Other divalent metal ions protected only against native lactoferrin. Log-phase cells were more resistant to killing than stationary-phase cells. These studies suggest that lactoferrin, especially in the form of the N-terminal peptides, may be an important nonimmune component of host mucosal defenses against Giardia lamblia.
人乳铁蛋白和牛乳铁蛋白及其衍生的N端肽在体外具有杀贾第虫的作用。Fe3 +而非Fe2 +可保护滋养体免受天然乳铁蛋白和肽的影响，尽管后者缺乏铁结合位点。其他二价金属离子仅能保护细胞免受天然乳铁蛋白的影响。对数期细胞比稳定期细胞对杀伤更具抗性。这些研究表明，乳铁蛋白，尤其是N端肽的形式，可能是宿主黏膜防御蓝氏贾第鞭毛虫的重要非免疫成分。
