乳铁蛋白和N端肽的杀贾第虫活性。
Giardicidal activity of lactoferrin and N-terminal peptides.
作者信息
Turchany J M, Aley S B, Gillin F D
机构信息
Division of Infectious Diseases, University of California at San Diego 92103-8416, USA.
出版信息
Infect Immun. 1995 Nov;63(11):4550-2. doi: 10.1128/iai.63.11.4550-4552.1995.
Abstract
Human and bovine lactoferrins and their derived N-terminal peptides were giardicidal in vitro. Fe3+, but not Fe2+, protected trophozoites from both native lactoferrin and peptides, although the latter lack iron-binding sites. Other divalent metal ions protected only against native lactoferrin. Log-phase cells were more resistant to killing than stationary-phase cells. These studies suggest that lactoferrin, especially in the form of the N-terminal peptides, may be an important nonimmune component of host mucosal defenses against Giardia lamblia.
摘要
人乳铁蛋白和牛乳铁蛋白及其衍生的N端肽在体外具有杀贾第虫的作用。Fe3 +而非Fe2 +可保护滋养体免受天然乳铁蛋白和肽的影响，尽管后者缺乏铁结合位点。其他二价金属离子仅能保护细胞免受天然乳铁蛋白的影响。对数期细胞比稳定期细胞对杀伤更具抗性。这些研究表明，乳铁蛋白，尤其是N端肽的形式，可能是宿主黏膜防御蓝氏贾第鞭毛虫的重要非免疫成分。
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本文引用的文献
1
Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment.乳铁蛋白及一种胃蛋白酶衍生的乳铁蛋白肽片段的抗菌活性。
Infect Immun. 1993 Feb;61(2):719-28. doi: 10.1128/iai.61.2.719-728.1993.
2
Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin.乳铁蛋白B对白色念珠菌的杀伤作用，乳铁蛋白B是一种源自牛乳铁蛋白N端区域的强效抗菌肽。
Med Microbiol Immunol. 1993 May;182(2):97-105. doi: 10.1007/BF00189377.
3
Role of cell-binding in the antibacterial mechanism of lactoferricin B.细胞结合在乳铁蛋白B抗菌机制中的作用
J Appl Bacteriol. 1993 Nov;75(5):478-84.
4
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Acta Paediatr Jpn. 1994 Oct;36(5):585-91. doi: 10.1111/j.1442-200x.1994.tb03250.x.
6
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Infect Immun. 1981 May;32(2):655-60. doi: 10.1128/iai.32.2.655-660.1981.
7
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8
Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms.人乳铁蛋白的杀菌活性：多种微生物的敏感性
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9
The biological significance of lactoferrin.乳铁蛋白的生物学意义。
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10
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