产肠毒素大肠杆菌CS2菌毛的基因及其与CS1菌毛基因的互换性。
Genes for CS2 pili of enterotoxigenic Escherichia coli and their interchangeability with those for CS1 pili.
作者信息
Froehlich B J, Karakashian A, Sakellaris H, Scott J R
机构信息
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322, USA.
出版信息
Infect Immun. 1995 Dec;63(12):4849-56. doi: 10.1128/iai.63.12.4849-4856.1995.
Abstract
We have cloned and sequenced the DNA needed for production of CS2 pili in Escherichia coli K-12. The four open reading frames, cotB, cotA, cotC, and cotD, show homology with the genes needed for production of CS1 and CFA/I pili, which are also found on enterotoxigenic E. coli associated with human diarrheal disease. We also report that CotA plus CotB interact with the CS1 gene products CooC and CooD to form pili that can be visualized by electron microscopy and, conversely, that the CS1 gene products CooA and CooB interact with CotC and CotD to form pili.
摘要
我们已经克隆并测序了大肠杆菌K-12中产生CS2菌毛所需的DNA。四个开放阅读框，即cotB、cotA、cotC和cotD，与产生CS1和CFA/I菌毛所需的基因具有同源性，这些基因也存在于与人类腹泻病相关的产肠毒素大肠杆菌中。我们还报告称，CotA加CotB与CS1基因产物CooC和CooD相互作用形成菌毛，这些菌毛可以通过电子显微镜观察到，反之，CS1基因产物CooA和CooB与CotC和CotD相互作用形成菌毛。
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