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Infect Immun. 1995 Dec;63(12):4949-52. doi: 10.1128/iai.63.12.4949-4952.1995.
2
Expression of a pilin subunit BfpA of the bundle-forming pilus of enteropathogenic Escherichia coli in an aroA live salmonella vaccine strain.
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Distribution of the bundle-forming pilus structural gene (bfpA) among enteropathogenic Escherichia coli.束状菌毛结构基因（bfpA）在肠致病性大肠杆菌中的分布情况。
J Infect Dis. 1993 Oct;168(4):1037-41. doi: 10.1093/infdis/168.4.1037.
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Antibody response of children with enteropathogenic Escherichia coli infection to the bundle-forming pilus and locus of enterocyte effacement-encoded virulence determinants.患有肠致病性大肠杆菌感染的儿童对束状菌毛和肠细胞脱落位点编码的毒力决定因素的抗体反应。
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Characterization of fimbriae produced by enteropathogenic Escherichia coli.肠致病性大肠杆菌产生的菌毛的特性
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Molecular variation among type IV pilin (bfpA) genes from diverse enteropathogenic Escherichia coli strains.不同肠道致病性大肠杆菌菌株IV型菌毛（bfpA）基因的分子变异
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The type IV bundle-forming pilus of enteropathogenic Escherichia coli undergoes dramatic alterations in structure associated with bacterial adherence, aggregation and dispersal.肠致病性大肠杆菌的IV型束状菌毛在结构上会发生显著变化，这些变化与细菌的黏附、聚集和扩散有关。
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Cloning and characterization of the bundle-forming pilin gene of enteropathogenic Escherichia coli and its distribution in Salmonella serotypes.肠致病性大肠杆菌成束菌毛菌素基因的克隆、特性分析及其在沙门氏菌血清型中的分布
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Functional consequences of sequence variation in bundlin, the enteropathogenic Escherichia coli type IV pilin protein.肠道致病性大肠杆菌IV型菌毛蛋白bundlin序列变异的功能后果
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Monoclonal antibodies against all known variants of EspA: development of a simple diagnostic test for enteropathogenic Escherichia coli based on a key virulence factor.针对EspA所有已知变体的单克隆抗体：基于关键毒力因子开发用于肠致病性大肠杆菌的简易诊断测试。
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Novel topology of BfpE, a cytoplasmic membrane protein required for type IV fimbrial biogenesis in enteropathogenic Escherichia coli.BfpE的新型拓扑结构，一种肠道致病性大肠杆菌IV型菌毛生物合成所需的细胞质膜蛋白。
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Molecular variation among type IV pilin (bfpA) genes from diverse enteropathogenic Escherichia coli strains.不同肠道致病性大肠杆菌菌株IV型菌毛（bfpA）基因的分子变异
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Identification of enterotoxigenic Escherichia coli harboring longus type IV pilus gene by DNA amplification.通过DNA扩增鉴定携带长型IV菌毛基因的产肠毒素大肠杆菌。
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Effects of bfp mutations on biogenesis of functional enteropathogenic Escherichia coli type IV pili.bfp基因突变对功能性肠致病性大肠杆菌IV型菌毛生物合成的影响。
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本文引用的文献

1
A monoclonal antibody to Shigella dysenteriae serotype 13 cross-reacting with Shiga toxin.一种与志贺毒素交叉反应的针对痢疾志贺氏菌13型的单克隆抗体。
FEMS Microbiol Lett. 1993 Mar 1;107(2-3):343-7. doi: 10.1111/j.1574-6968.1993.tb06055.x.
2
A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells.肠道致病性大肠杆菌紧密附着上皮细胞所需的第二个染色体基因。
J Bacteriol. 1993 Aug;175(15):4670-80. doi: 10.1128/jb.175.15.4670-4680.1993.
3
Distribution of the bundle-forming pilus structural gene (bfpA) among enteropathogenic Escherichia coli.束状菌毛结构基因（bfpA）在肠致病性大肠杆菌中的分布情况。
J Infect Dis. 1993 Oct;168(4):1037-41. doi: 10.1093/infdis/168.4.1037.
4
Adhesion and its role in the virulence of enteropathogenic Escherichia coli.黏附及其在肠致病性大肠杆菌毒力中的作用。
Clin Microbiol Rev. 1994 Apr;7(2):152-73. doi: 10.1128/CMR.7.2.152.
5
The eaeB gene of enteropathogenic Escherichia coli is necessary for signal transduction in epithelial cells.肠致病性大肠杆菌的eaeB基因对于上皮细胞中的信号转导是必需的。
Infect Immun. 1994 Jul;62(7):3038-40. doi: 10.1128/iai.62.7.3038-3040.1994.
6
Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes.4型菌毛、DNA转移系统、丝状噬菌体和蛋白质分泌装置组装中的常见组件：一种形成表面相关蛋白复合物的通用系统。
Mol Microbiol. 1993 Oct;10(2):233-43. doi: 10.1111/j.1365-2958.1993.tb01949.x.
7
Characterization of fimbriae produced by enteropathogenic Escherichia coli.肠致病性大肠杆菌产生的菌毛的特性
J Bacteriol. 1993 Nov;175(22):7391-403. doi: 10.1128/jb.175.22.7391-7403.1993.
8
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.不同肠道细菌病原体中保守的肠上皮细胞脱落遗传位点。
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1664-8. doi: 10.1073/pnas.92.5.1664.
9
Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation.肠道致病性大肠杆菌含有一种假定的III型分泌系统，该系统对于输出参与黏附和损毁病变形成的蛋白质是必需的。
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7996-8000. doi: 10.1073/pnas.92.17.7996.
10
Identification of enteropathogenic Escherichia coli by PCR-based detection of the bundle-forming pilus gene.基于聚合酶链式反应检测束状菌毛基因鉴定肠致病性大肠杆菌
J Clin Microbiol. 1995 May;33(5):1375-7. doi: 10.1128/jcm.33.5.1375-1377.1995.

针对致病性大肠杆菌束状菌毛的单克隆抗体。

Monoclonal antibodies specific for the bundle-forming pilus of enteropathogenic Escherichia coli.

作者信息

Girón J A, Qadri F, Azim T, Jarvis K J, Kaper J B, Albert M J

机构信息

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA.

出版信息

Infect Immun. 1995 Dec;63(12):4949-52. doi: 10.1128/iai.63.12.4949-4952.1995.

DOI:10.1128/iai.63.12.4949-4952.1995
PMID:7591164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173713/
Abstract

The bundle-forming pilus (BFP) produced by enteropathogenic Escherichia coli (EPEC) is associated with the presence of a large EPEC adherence factor plasmid and the formation of localized adherence clusters on tissue culture cells. Three mouse monoclonal antibodies (ICA2, ICA3, and ICA4) were produced against BFP purified from EPEC B171 (O111:NM). These monoclonal antibodies reacted in immunoblots with different epitopes of the 19.5-kDa bundlin subunit of BFP of heterologous EPEC. These reagents could serve as diagnostic tools for the identification of EPEC as well as for studying the role of BfpA in the interaction of EPEC with eukaryotic cells.

摘要

肠致病性大肠杆菌（EPEC）产生的束状菌毛（BFP）与一个大型EPEC黏附因子质粒的存在以及在组织培养细胞上形成局部黏附簇有关。针对从EPEC B171（O111:NM）纯化的BFP制备了三种小鼠单克隆抗体（ICA2、ICA3和ICA4）。这些单克隆抗体在免疫印迹中与异源EPEC的BFP的19.5-kDa菌毛束蛋白亚基的不同表位发生反应。这些试剂可作为鉴定EPEC的诊断工具，也可用于研究BfpA在EPEC与真核细胞相互作用中的作用。