枯草芽孢杆菌spo0H、kinB、ftsAZ和pbpE启动子上AbrB结合位点的描绘以及利用衍生的同源性鉴定bsuB1甲基化酶启动子中一个先前未被怀疑的结合位点。
Delineation of AbrB-binding sites on the Bacillus subtilis spo0H, kinB, ftsAZ, and pbpE promoters and use of a derived homology to identify a previously unsuspected binding site in the bsuB1 methylase promote.
作者信息
Strauch M A
机构信息
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Bacteriol. 1995 Dec;177(23):6999-7002. doi: 10.1128/jb.177.23.6999-7002.1995.
Abstract
DNase I footprinting experiments showed that AbrB binds to the regulatory regions of the spo0H, kinB, ftsAZ, and pbpE genes. A conserved motif was found in these and other AbrB-binding sites. A search for Bacillus subtilis DNA sequences containing this motif led to the prediction that AbrB would bind to the promoter controlling the bsuB1 methylase gene. DNase I footprinting experiments confirmed this prediction.
摘要
脱氧核糖核酸酶I足迹实验表明，AbrB与spo0H、kinB、ftsAZ和pbpE基因的调控区域结合。在这些以及其他AbrB结合位点中发现了一个保守基序。对含有该基序的枯草芽孢杆菌DNA序列进行搜索，结果预测AbrB会与控制bsuB1甲基化酶基因的启动子结合。脱氧核糖核酸酶I足迹实验证实了这一预测。
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