Corssmit E P, Heyligenberg R, Endert E, Sauerwein H P, Romijn J A
Department of Internal Medicine, University of Amsterdam, The Netherlands.
J Clin Endocrinol Metab. 1995 Nov;80(11):3140-4. doi: 10.1210/jcem.80.11.7593416.
Both hyper- and hypothyroidism have been reported during prolonged recombinant human interferon-alpha (rhIFN alpha) therapy. To assess the short term effects of IFN alpha therapy on thyroid hormone metabolism, we measured thyroid hormone concentrations in eight healthy volunteers for 24 h after sc administration of rhIFN alpha and, on another occasion, after sc administration of saline (control study). There were no effects of rhIFN alpha on plasma T4 and free T4 or on thyroid hormone binding index. However, rhIFN alpha induced a significant decrease in the plasma concentrations of TSH (P < 0.03) and T3 (P < 0.02) compared with those in the control study, associated with an increase in rT3 concentrations (P < 0.02). IFN alpha induced a moderate increase in interleukin-6 (IL-6) concentrations (P < 0.02 vs. control study), whereas IL-1 and tumor necrosis factor concentrations remained below the detection limit in all subjects. It is concluded that IFN alpha administration induces major changes in thyroid hormone metabolism, possibly mediated in part by IL-6. The acute effects of rhIFN alpha mimic the euthyroid sick syndrome and appear to be different from the effects of chronic rhIFN alpha treatment on thyroid hormone metabolism.
长期重组人干扰素-α（rhIFNα）治疗期间，既有甲状腺功能亢进的报道，也有甲状腺功能减退的报道。为评估IFNα治疗对甲状腺激素代谢的短期影响，我们对8名健康志愿者皮下注射rhIFNα后24小时以及在另一次皮下注射生理盐水后（对照研究），测量了甲状腺激素浓度。rhIFNα对血浆总甲状腺素（T4）、游离T4或甲状腺激素结合指数均无影响。然而，与对照研究相比，rhIFNα导致促甲状腺激素（TSH）血浆浓度显著降低（P < 0.03），三碘甲状腺原氨酸（T3）血浆浓度显著降低（P < 0.02），同时反三碘甲状腺原氨酸（rT3）浓度升高（P < 0.02）。IFNα导致白细胞介素-6（IL-6）浓度适度升高（与对照研究相比，P < 0.02），而在所有受试者中，IL-1和肿瘤坏死因子浓度均低于检测限。结论是，给予IFNα会引起甲状腺激素代谢的重大变化，可能部分由IL-6介导。rhIFNα的急性作用模拟了非甲状腺疾病综合征，似乎与慢性rhIFNα治疗对甲状腺激素代谢的作用不同。
