Friss A B, Cohen P R, Bruce S, Duvic M
Department of Dermatology, University of Texas-Houston Medical School 77030, USA.
J Am Acad Dermatol. 1995 Nov;33(5 Pt 2):891-5. doi: 10.1016/0190-9622(95)90430-1.
Mycosis fungoides, which is characterized by a malignant infiltrate of T lymphocytes involving the epidermis, can be confused with other inflammatory skin diseases. We report the case of a patient with skin lesions containing an infiltrate of atypical lymphocytes with epidermotropism. This patient's condition was initially diagnosed as mycosis fungoides. Repeated biopsy samples had the histologic features of chronic cutaneous lupus erythematosus. The patient had a strongly positive antinuclear antibody response and the clinical lesions responded to hydroxychloroquine, however, and these findings led to an altered diagnosis. Other disorders that either clinically or histologically mimic mycosis fungoides are reviewed, and the diagnostic evaluation of patients in whom mycosis fungoides is suspected is summarized. Chronic cutaneous lupus erythematosus should be added to the list of diseases that can mimic mycosis fungoides.
蕈样肉芽肿以累及表皮的T淋巴细胞恶性浸润为特征，可能与其他炎症性皮肤病相混淆。我们报告了1例皮肤病变中有向表皮性非典型淋巴细胞浸润的患者。该患者的病情最初被诊断为蕈样肉芽肿。重复活检样本具有慢性皮肤型红斑狼疮的组织学特征。然而，该患者抗核抗体反应呈强阳性，临床病变对羟氯喹有反应，这些发现导致了诊断的改变。本文回顾了其他在临床或组织学上酷似蕈样肉芽肿的疾病，并总结了疑似蕈样肉芽肿患者的诊断评估。慢性皮肤型红斑狼疮应被列入可酷似蕈样肉芽肿的疾病清单中。
