Van Lieshout L, Polderman A M, De Vlas S J, De Caluwé P, Krijger F W, Gryseels B, Deelder A M
Department of Parasitology, University of Leiden, Netherlands.
J Infect Dis. 1995 Nov;172(5):1336-42. doi: 10.1093/infdis/172.5.1336.
Serum circulating anodic antigen (CAA) and circulating cathodic antigen (CCA) concentrations, as a possible direct measure of worm burden, were compared with fecal egg counts in a heavily Schistosoma mansoni-infected population from Zaire to allow differentiation between worm loads and worm fecundity in relation to age and intensity of infection. Of the 517 subjects, 95% excreted eggs and 97% demonstrated circulating antigens. Fecal egg counts showed an age-related pattern characteristic for an area in which schistosomiasis is endemic with intense transmission levels. Regression analysis showed that antigen concentrations were strongly associated with egg counts. For CAA, but not for CCA, this relation was found to be nonlinear, which would be consistent with density-dependent fecundity or crowding. The trend was uniform for all age groups, which for this particular population indicated a genuine reduction of worm loads rather than reduced worm fecundity with age of the host.
血清循环阳极抗原（CAA）和循环阴极抗原（CCA）浓度作为衡量虫负荷的一种可能的直接指标，在来自扎伊尔的曼氏血吸虫重度感染人群中与粪便虫卵计数进行了比较，以区分与年龄和感染强度相关的虫负荷和虫繁殖力。在517名受试者中，95%的人排出虫卵，97%的人显示有循环抗原。粪便虫卵计数呈现出一种与年龄相关的模式，这是血吸虫病高度流行地区的典型特征。回归分析表明，抗原浓度与虫卵计数密切相关。对于CAA而非CCA，发现这种关系是非线性的，这与密度依赖性繁殖力或拥挤现象相符。所有年龄组的趋势都是一致的，对于这个特定人群而言，这表明随着宿主年龄的增长，虫负荷确实减少了，而不是虫繁殖力降低了。
