de Malmanche S A, Martin D R
ESR Health: Communicable Disease Centre, Porirua, New Zealand.
Med Microbiol Immunol. 1994 Dec;183(6):299-306. doi: 10.1007/BF00196680.
M protein enables Group A streptococci to resist phagocytosis. Protective immunity is considered to be mediated by opsonic antibodies directed against this M protein. In recent studies we have shown that genetically distinct populations exist within an M-type. The question asked in this study was whether human and rabbit type specific M1 antibody was opsonic for all strains of M-type 1, irrespective of their restriction fragment length polymorphism type. When locating a blood donor from among our staff for use in the indirect bactericidal test, selective variation in opsonic ability was demonstrated by one person. Subsequent testing of 44 randomly selected human sera revealed that 11 (25%) had opsonic antibody. Of these 11, 6 opsonised all seven strains and 5 demonstrated selective opsonisation. We conclude that opsonic antibody is not necessarily type specific but may be strain specific.
M蛋白使A组链球菌能够抵抗吞噬作用。保护性免疫被认为是由针对这种M蛋白的调理素抗体介导的。在最近的研究中，我们已经表明在一种M型内存在基因上不同的群体。本研究提出的问题是，人源和兔源的型特异性M1抗体对于所有M1型菌株是否具有调理作用，而不论其限制性片段长度多态性类型如何。当从我们的工作人员中寻找一名献血者用于间接杀菌试验时，发现有一人的调理能力存在选择性差异。随后对44份随机选择的人血清进行检测，发现11份（25%）含有调理素抗体。在这11份血清中，6份能调理所有7株菌株，5份表现出选择性调理作用。我们得出结论，调理素抗体不一定是型特异性的，而可能是菌株特异性的。
