化脓性链球菌emm12型分离株中的drs（远距离相关，原文如此）基因多态性
drs (Distantly related sic) gene polymorphisms among emm12-type Streptococcus pyogenes isolates.
作者信息
Brandt Claudia M, Haase Gerhard, Spellerberg Barbara, Holland Regina, Lütticken Rudolf
机构信息
Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, 52057 Aachen, Germany.
出版信息
J Clin Microbiol. 2003 Apr;41(4):1794-7. doi: 10.1128/JCM.41.4.1794-1797.2003.
Abstract
Twenty-eight emm12-type Streptococcus pyogenes isolates from patients with invasive and noninvasive infections or from asymptomatic carriers were genetically typed. Sequencing of drs (distantly related sic [streptococcal inhibitor of complement]) genes identified two novel alleles and revealed a polymorphism for drs similar to that of sic. No association was observed between the five different drs alleles and the five restriction patterns of the vir regulon for the isolates studied. These data suggest that drs sequencing may be useful for further differentiation of S. pyogenes isolates with emm12 and identical vir regulon restriction patterns.
摘要
对28株来自侵袭性和非侵袭性感染患者或无症状携带者的emm12型化脓性链球菌分离株进行了基因分型。对drs（与sic[链球菌补体抑制剂]远缘相关）基因进行测序，鉴定出两个新等位基因，并揭示了drs与sic相似的多态性。在所研究的分离株中，未观察到五种不同的drs等位基因与vir调控子的五种限制性酶切图谱之间存在关联。这些数据表明，drs测序可能有助于进一步区分具有emm12和相同vir调控子限制性酶切图谱的化脓性链球菌分离株。
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