Wood B, Currie J
University of Melbourne, Department of Community Medicine and Public Health, Parkville, Victoria, Australia.
Metab Brain Dis. 1995 Mar;10(1):57-72. doi: 10.1007/BF01991783.
Thirty two cases of acute Wernicke's encephalopathy were observed in a period of 33 months, and prior to the mandatory thiamine enrichment of Australian bread-making flour in 1991. These cases were carefully assessed by multiple tests at specified intervals prior to, and following thiamine administration until discharge from hospital. Structured scoring of neurological signs and symptoms, CT scans, psychometry, nutritional measurements, and liver biopsies were performed. There was variation in the presentation and severity of clinical signs and symptoms and in response to treatment. All patients had alcohol-related liver disease, and the results indicated that fatty liver was important in presentation and in response to treatment with thiamine. Other forms of alcohol related brain damage were present in these patients, most of whom were in the 4th or 5th decade of life and had been drinking beer to excess for more than 20 years.
在1991年澳大利亚面包制作面粉强制添加硫胺素之前的33个月内，共观察到32例急性韦尼克脑病患者。在给予硫胺素之前及之后，按照特定时间间隔对这些病例进行多次仔细评估，直至出院。对神经体征和症状进行结构化评分、进行CT扫描、心理测试、营养测量以及肝活检。临床体征和症状的表现及严重程度以及对治疗的反应存在差异。所有患者均患有酒精性肝病，结果表明脂肪肝在疾病表现及硫胺素治疗反应中起重要作用。这些患者还存在其他形式的酒精相关性脑损伤，他们大多处于40或50多岁，过量饮用啤酒超过20年。
