Shapovalova K B, Shuvaev V T, Zhuravin I A, Pominova E V
Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Mar-Apr;45(2):297-304.
Influence of cholinergic activation of dorsal (caudo-putamen) and ventral (accumbens) striatum on active avoidance learning was studied in chronic experiments in Sprague-Dawley male rats. The results obtained on the same behavioural model testify to specific roles of dorsal and ventral cholinergic systems in the control of motor behaviour. Single carbacholine microinjection into the right Accumbens increased the level of correct responses on the first and subsequent learning days. Similar microinjection into the left accumbens on the first training day improved the level of correct responses on the second and the third learning days. Microinjections into the dorsal striatum did not change active avoidance learning in T maze. Changes in locomotor activity of the animals of different experimental groups were principally of the same nature, i.e., the level of locomotor activity in the open field decreased from trial to trial in all the groups. Carbacholine microinjection did not change spontaneous locomotion in rats. However, there were variations in modifications of locomotor activity induced by microinjections into accumbens depending on localization of the cannula. Injection into the lateral accumbens induced the most pronounced changes. This fact testifies to the functional heterogeneity of this small nucleus.
在对雄性斯普拉格-道利大鼠进行的慢性实验中，研究了背侧（尾壳核）和腹侧（伏隔核）纹状体胆碱能激活对主动回避学习的影响。在同一行为模型上获得的结果证明了背侧和腹侧胆碱能系统在控制运动行为中的特定作用。向右侧伏隔核单次微量注射卡巴胆碱可提高首次及后续学习日的正确反应水平。在首次训练日向左侧伏隔核进行类似的微量注射可提高第二次和第三次学习日的正确反应水平。向背侧纹状体微量注射并未改变T迷宫中的主动回避学习。不同实验组动物的运动活动变化主要性质相同，即所有组在旷场中的运动活动水平逐次降低。向大鼠微量注射卡巴胆碱并未改变其自发运动。然而，根据套管的定位，向伏隔核微量注射所诱导的运动活动改变存在差异。向外侧伏隔核注射引起的变化最为明显。这一事实证明了这个小核的功能异质性。
