Smedby O, Johansson J, Mölgaard J, Olsson A G, Walldius G, Erikson U
Department of Diagnostic Radiology, Uppsala University, Sweden.
Arterioscler Thromb Vasc Biol. 1995 Jul;15(7):912-7. doi: 10.1161/01.atv.15.7.912.
The degree of atherosclerosis in the inner and outer curvature of the femoral artery was studied by using digitized angiography and edge-roughness calculations in 301 hyperlipidemic patients. When the two edges of the vessel were compared no significant difference was seen, but when the local curvature was taken into account, inner curves were found to be more atherosclerotic than outer curves, and both inner and outer curves were more affected than straight segments. The same pattern was encountered in subpopulations defined by clinical or blood lipid criteria. The suggested explanation is that flow disturbances such as low shear rates or separated flow, which tend to arise along the inner curvature, promote the development of atherosclerosis.
通过数字化血管造影术和边缘粗糙度计算，对301例高脂血症患者股动脉内、外曲率处的动脉粥样硬化程度进行了研究。比较血管的两条边缘时，未发现显著差异，但考虑局部曲率时，发现内曲率处比外曲率处动脉粥样硬化更严重，且内、外曲率处均比直线段受影响更大。在根据临床或血脂标准定义的亚组中也观察到了相同的模式。推测的解释是，诸如低剪切率或分离流等流动紊乱往往沿内曲率出现，会促进动脉粥样硬化的发展。
