Smedby O, Högman N, Nilsson S, Erikson U
Department of Diagnostic Radiology, Uppsala University, Sweden.
J Biomech. 1993 Sep;26(9):1105-15. doi: 10.1016/s0021-9290(05)80009-0.
Disturbances in arterial flow are believed to influence the localization and development of atherosclerotic plaques. The femoral arteries of 26 patients were studied with cineangiography, after which the films were digitized and analyzed with an image analysis computer. The image sequence was converted to a set of time-intensity curves, from which time parameters were calculated, representing the arrival time of the contrast medium at each pixel. In the resulting parametric images, zones of delayed contrast filling (ZDF) were identified by an adaptive thresholding, which identifies lighter regions within the vessel, excluding the smallest ones. The ZDF, which have been shown, in a model study, to correspond to disturbed flow, were more frequent in the inner curvature than in the outer curvature of the curved vessels. Accordingly, they were more frequent along the lateral wall than along the medial wall of the artery. Several ZDF were also found in the vicinity of bifurcations. Most of the findings tally closely with fluid mechanical theory. In future studies, flow disturbances are to be correlated with the progression of atherosclerotic lesions.
动脉血流紊乱被认为会影响动脉粥样硬化斑块的定位和发展。对26例患者的股动脉进行了血管造影研究，之后将影片数字化并使用图像分析计算机进行分析。图像序列被转换为一组时间-强度曲线，从中计算出时间参数，代表造影剂到达每个像素的时间。在生成的参数图像中，通过自适应阈值处理识别延迟造影剂充盈区（ZDF），该阈值处理可识别血管内较亮的区域，但不包括最小的区域。在模型研究中已表明，ZDF与血流紊乱相对应，在弯曲血管的内曲率处比外曲率处更常见。因此，它们在动脉的侧壁比在内侧壁更常见。在分叉附近也发现了几个ZDF。大多数研究结果与流体力学理论密切吻合。在未来的研究中，血流紊乱将与动脉粥样硬化病变的进展相关联。
