Smedby O, Nilsson S, Bergstrand L
Department of Diagnostic Radiology, Uppsala University, Sweden.
J Biomech. 1996 Apr;29(4):543-7. doi: 10.1016/0021-9290(95)00070-4.
Angiography and post-mortem studies have indicated that disturbed blood flow may promote atherogenesis. Our aim was to demonstrate flow disturbances in vivo and correlate them to the subsequent development of atherosclerosis. The femoral arteries of 17 patients with early atherosclerosis were studied with cineangiography. The films are digitized and analyzed with an image analysis computer. From the time-intensity curves, the arrival time of the contrast medium at each pixel was calculated. In the resulting parametric images, the computer identified zones of delayed contrast filling, (ZDF) which have been shown to correspond to disturbed flow. The progression or regression of atherosclerosis was followed with another angiography 3 years later by computing changes in edge roughness. Arterial segments without flow disturbances (defined as ZDF) showed a more marked decrease in edge roughness than those with flow disturbances (p < 0.05). In addition, the edge roughness tended to increase more in segments with larger ZDF area. Angiographic studies of fluid mechanics and atherogenesis are feasible, but larger patient materials are needed.
血管造影和尸检研究表明，血流紊乱可能促进动脉粥样硬化的发生。我们的目的是在体内证明血流紊乱，并将其与随后动脉粥样硬化的发展相关联。对17例早期动脉粥样硬化患者的股动脉进行了电影血管造影研究。将影片数字化并用图像分析计算机进行分析。根据时间-强度曲线，计算造影剂到达每个像素的时间。在生成的参数图像中，计算机识别出造影剂延迟充盈区（ZDF），已证明其与血流紊乱相对应。3年后通过计算边缘粗糙度的变化，用另一项血管造影术跟踪动脉粥样硬化的进展或消退。无血流紊乱（定义为ZDF）的动脉节段边缘粗糙度的降低比有血流紊乱的节段更明显（p<0.05）。此外，ZDF面积较大的节段边缘粗糙度往往增加得更多。流体力学与动脉粥样硬化的血管造影研究是可行的，但需要更大的患者样本。
