Watt P R, Robins G M, Galloway A M, O'Boyle D A
Department of Companion Animal Medicine and Surgery, University of Queensland, St Lucia, Australia.
J Am Vet Med Assoc. 1995 Jul 1;207(1):67-70.
Medical records of 10 dogs in which fungal infection was diagnosed between 1982 and 1990 were reviewed. In each dog, infection was determined to be caused by a single species of fungus, either Aspergillus terreus, Penicillium sp, Paecilomyces sp, Chrysosporium sp, or Pseudallescheria boydii. Nine dogs were German Shepherd Dogs; 1 was a German Shepherd Dog cross, and 9 were females. The most common clinical signs were signs of neck or back pain (9 dogs), weight loss (7 dogs), anorexia (6 dogs), pyrexia (6 dogs), paresis (3 dogs), and paralysis (3 dogs). All 10 dogs had evidence of multiple sites of diskospondylitis. Urine sediment was examined in 6 dogs, and all 6 had fungal hyphae. Urine samples from these dogs produced a medium to heavy pure growth of fungi when placed on Sabaraud's medium. Predisposing causes were not identified in any of the dogs. Four dogs were euthanatized immediately after diagnosis because of paralysis or paresis. The other 6 dogs were treated, and 4 of the 6 received itraconazole. One dog was euthanatized for an unrelated problem after 21 months of treatment; 1 dog was still alive after 4 years of continuous treatment with itraconazole. The other 4 dogs were euthanatized because of eventual paralysis or paresis. Our results suggest that German Shepherd Dogs are predisposed to infection with opportunistic fungi, possibly because of a specific inability to mount an effective response. This predisposition needs to be further studied.
回顾了1982年至1990年间诊断为真菌感染的10只犬的病历。每只犬的感染被确定为由单一真菌种类引起，即土曲霉、青霉属、拟青霉属、金孢子菌属或博伊德假阿利什霉。9只为德国牧羊犬；1只为德国牧羊犬杂交犬，且9只为雌性。最常见的临床症状为颈部或背部疼痛（9只犬）、体重减轻（7只犬）、厌食（6只犬）、发热（6只犬）、轻瘫（3只犬）和瘫痪（3只犬）。所有10只犬均有椎间盘脊椎炎多部位的证据。6只犬进行了尿沉渣检查，所有6只均有真菌菌丝。将这些犬的尿液样本接种于沙氏培养基上时，产生了中度至重度的真菌纯培养生长。未在任何一只犬中确定易感因素。4只犬在诊断后因瘫痪或轻瘫立即实施安乐死。另外6只犬接受了治疗，其中4只接受了伊曲康唑治疗。1只犬在治疗21个月后因 unrelated问题实施安乐死；1只犬在接受伊曲康唑连续治疗4年后仍然存活。另外4只犬因最终出现瘫痪或轻瘫而实施安乐死。我们的结果表明，德国牧羊犬易感染机会性真菌，可能是因为其特定的无法产生有效反应的能力。这种易感性需要进一步研究。
